Gender disparities in treatment of cardiovascular risk are well established. However, the reasons for them are not fully understood. In the present study we leveraged artificial intelligence technology to shed light on a previously unexplored phenomenon – rejection of statin therapy by patients – and found that it involved significant gender differences. These newly identified disparities could be an important contributor to the lower rates of statin therapy and LDL control in women. The present study therefore has established a novel area of women’s health research that could potentially bring about significant improvements in quality and outcomes of cardiovascular care of women.