The acute inflammatory response is essential for host defense and requires active resolution to return to homeostasis. Failed resolution plays a major role in the development of chronic inflammation and the etiology of multiple diseases such as arthritis, periodontitis, thrombosis, fibrosis, and cancer. The resolution of inflammation is an active process driven by specialized pro-resolving lipid mediators (SPM) that arise from polyunsaturated fatty acids such as arachidonic acid, docosahexaenoic acid, eicosapentaenoic acid, and docosapentaenoic acid. SPMs counter-regulate pro-inflammatory mediators, increase uptake of bacteria, cellular debris, and apoptotic neutrophils, and decrease the influx of infiltrating leukocytes. Granuloma formation occurs during inflammation when the immune system is unable to eliminate bacteria, fungi, or a foreign body and instead forms an enclosure. Chronic granuloma formation leads to necrotic lesions, loss of tissue regeneration, loss of tissue/organ function, and potentially death. The role of specialized pro-resolving lipid mediators in granuloma formation and subsequent loss of tissue regeneration and organ function is not known. Here we identified a novel peptide-conjugated pro- resolving lipid mediator, 4,5-Resolvin Conjugate in Tissue Regeneration-1, that significantly decreases granuloma formation as well as increases the amount of tissue regenerated and accelerates the time required for tissue regeneration.