The most common reason for revision after chest masculinization is hypertrophic scarring and hormones may play a role. Prior studies have demonstrated that the sex hormones can interact with wound healing, but none have examined these effects in a transgender model.
We present a proof-of-concept animal model that recreates the hormone environment of gender affirming surgery. We found that exogenous testosterone administered to XX/OVX mice impairs wound healing, both on macroscopic planimetry and on histologic evaluation.
This report represents a pilot study, and our team is currently striving to elucidate many questions regarding mechanistic investigation of underlying pathways and validation in human clinical studies. Preliminary results suggest differences in wound healing between castrated XX and XY mice treated with testosterone, suggesting not just a difference in hormone milieu but potentially an epigenetic difference in wound healing response despite identical hormone profiles.