Epilepsy is one of the most common neurological disorders with a one-year prevalence of 7/1,000, causing significant morbidity and a high cost to society. Acquired epilepsy is also often drug-resistant and requires surgery. However, the seizure-free condition, is not achieved in 20-30% of TLE surgeries. In acquired forms of epilepsy, a relatively lengthy seizure-free period is thought to follow an initial precipitating event. However, what functional roles the changes that occur during such period have in relation to determining the ensuing emergence of overt epilepsy is poorly understood.