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Mary Grace Whelan, BS
Pronouns
She/Her/Hers
Job Title
Clinical Research Assistant II
Academic Rank
Department
Medicine
Authors
Mary Grace Whelan., BS, Keigo Hayashi, MD, Sara Tedeschi, MD, MPH
Principal Investigator
Sara Tedeschi
Research Category: Musculoskeletal/Orthopedics/Sports Medicine
Tags
Background: Calcium pyrophosphate deposition (CPPD) disease prevalence is similar to gout and OA, yet CPPD outcomes research greatly lags behind these other forms of arthritis. We compared validated patient-reported outcome measures in a prospective single center CPPD registry versus clinic-based gout and OA cohorts from the literature.
Methods: Potential CPPD registry participants were identified using EHR data from BWH. Presence CPPD was assessed by manual EHR review and surveys. Baseline surveys included the GAQ 2.0, RAPID3, and WOMAC. We used t-tests to compare responses in the CPPD registry against historical gout and OA controls from cohort studies that reported the same outcome measures.
Results: CPPD patients reported significantly greater unmet treatment need than gout patients. Overall disease severity scores in CPPD indicated lower disease activity than in gout and similar disease activity to OA. CPPD patients had significantly worse pain and stiffness scores than patients with mild OA, and significantly better function scores than patients with severe OA.
Conclusion: These preliminary data suggest that patients with CPPD may experience pain comparable to gout and OA, though future studies are needed to validate these outcome measures in CPPD. Patients with CPPD reported substantial unmet treatment needs.
Background: Calcium pyrophosphate deposition (CPPD) disease is a common crystalline arthritis that causes chronic and acute joint pain, redness, and swelling. Prevalence of CPPD is similar to gout and OA, yet CPPD research greatly lags behind these other forms of arthritis. We compared survey responses from CPPD patients at the Brigham to published responses of prior gout and osteoarthritis cohorts from other institutions.
Results: CPPD patients reported significantly greater unmet treatment need than gout patients. Overall disease severity scores in CPPD indicated lower disease activity than in gout and similar disease activity to OA. CPPD patients had significantly worse pain and stiffness scores than patients with mild OA, and significantly better function scores than patients with severe OA.
Conclusion: These preliminary data suggest that patients with CPPD may experience pain comparable to gout and OA, though future studies are needed to validate these outcome measures in CPPD. Patients with CPPD reported substantial unmet treatment needs.
