Clinical Research Assistant
Nicholas Morreale, Megan Powell, Julia Klopfer, John Almeida, Xiaofang Li, John Kupleian, Amy Sherman, M.D., Lindsey Baden, M.D.
Amy Sherman, MD
Research Category: COVID-19
Background: Despite highly effective SARS-CoV-2 mRNA vaccines, breakthrough infections persist among healthy individuals. Understanding breakthrough infections is necessary to inform public health strategies.
Methods: A prospective cohort study of healthy adults was conducted at Brigham and Women’s Hospital with longitudinal follow up through the recommended 3-dose or 4-dose (individuals >50 years old) mRNA COVID vaccine series. COVID-19 infection prevalence and time between vaccination and infection was followed in all patients.
Results: 68 participants were enrolled and followed from December 17,2020 to August 31, 2022. The cohort was composed of 39 (57%) females, with a median age 28.09 (IQR 24.05-53.47), and was predominately white (73%). Of the study cohort population, 58/68 (85%) received 3 doses of mRNA vaccines, and 6/68 (9%) received 4 doses. Infection prevalence among volunteers was 51%, with May 2022 having peak incidence of COVID-19. The average time between most recent vaccination to infection was 172 days (median 189, IQR 114.5 – 232.5).
Conclusion: Increased rates of SARS-COV-2 infections have been reported in the first half of 2022, suggesting antibody decay, decreased efficacy of vaccine immunity against variants of concern, and/or relaxation of social mitigation factors leading to increased infection rates.
Background: Despite well functioning COVID-19 vaccines people around the globe are still contracting and spreading the virus. Understanding how the virus is transmitted among a vaccinated population is necessary to help decide what public health strategies can help reduce rate of infection,
How We Operated: A group of healthy participants were followed over the course of the pandemic and typically dosing schedule. We asked them to report to us when they received COVID-19 vaccines and when they tested positive for the virus.
Results: Out of 68 participants that were followed throughout the study over half were white(73%), female(57%), and the middle age of the participants hovered around 28. 58 out of the 68 paticpants received 3 dose of the COVID vaccine, with 6 of those getting a fourth dose. 51% of the participants contracted COVID during the study. The month with the most cases was May 2022. The average time from most recent vaccine to COVID infection was 172 days.
Conclusion: Increased rates of COVID infections have been reported in the first half of 2022, suggesting the vaccines only protect people for a certain period of time, an evolving virus as a result of the vaccine protection and/or relaxation of social distancing leading to increased infection rates.