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Nicole Porio, BA
Pronouns
She/Her/Hers
Job Title
Research Assistant I
Academic Rank
Department
Medicine
Authors
Nicole Porio BA, Darsiya Krishnathasan BS, Antoine Bejjani MD, Candrika D Khairani MD, MMSc, Andre Armero BS, Gregory Piazza MD, MS, Samuel Z Goldhaber MD, Umberto Campia MD, MS
Principal Investigator
Umberto Campia, MD, MS
Research Category: Cardiovascular, Diabetes, and Metabolic Disorders
Tags
Background: Patients with acute aortic syndromes (AAS) often have a history of coronary artery disease (CAD). We assessed the impact of a history of CAD on 1-year mortality in patients with an AAS.
Methods: We undertook a retrospective analysis of consecutive patients admitted to our tertiary care center with a confirmed AAS from January 2014 to April 2021.
Results: A total of 313 patients were included. Compared to those without CAD, patients with CAD were older and had a higher proportion of several comorbidities (Table 1). Thirty-one (48.4%) patients with CAD had died at 1-year compared with fifty-nine (23.7%) patients with no CAD. Patients with and without CAD had a similar frequency of MI and stroke within 1-year after their AAS. Cardiovascular death was higher among patients with CAD than patients without CAD (34.4% vs 16.9%; p=0.002). Patients presenting with AAS and a history of CAD had 2-fold increased odds of mortality (adjusted odds ratio = 2.15; 95% confidence interval 1.17-3.95), after adjusting for age, sex, and type of AAS.
Conclusion: In AAS patients, a history of CAD was independently associated with increased all-cause mortality at 1-year. These patients had a higher proportion of cardiovascular-related deaths compared to those without CAD.
Background: Patients with acute aortic disease (AAD) often have a history of coronary artery disease (CAD). Limited data exist on mortality the year following the acute aortic event. We examined the impact of a history of CAD on 1-year mortality in patients with an AAD.
Methods: Retrospective analysis of all patients with a confirmed case of AAD at Brigham and Women’s Hospital from January 2014 to April 2021.
Results: A total of 313 patients were included in our analysis. Patients with CAD were older and had a higher proportion of co-existing diseases (Table). Greater number of patients with CAD died (48.4%) at 1-year compared to patients without (23.7%). After adjustment for age, sex, and type of AAD, CAD increased the risk of all-cause mortality (odds ratio = 2.15; 95% confidence interval 1.17-3.95). Frequencies of heart attack and stroke at 1 year were low (0.9% and 0.6%, respectively). Cardiovascular-related death was not significantly different between patients with CAD (34.4%) compared to patients without CAD (16.9%) (p=0.09).
Conclusion: In AAD patients, CAD was independently associated with increased all-cause mortality at 1-year. Rates of heart attack and stroke at 1 year were low. No significant difference was noted in cardiovascular death.
