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Sleep disturbance and insufficiency has been shown to be associated with both the development and progression of Alzheimer’s disease and with all-cause mortality. Among a cohort of older adults without dementia, adults with high sleep fragmentation had a 1.5-fold risk of developing Alzheimer’s Disease compared to those with low sleep fragmentation. Similarly, in a prospective analyses, sleep disturbance was linked with incident cognitive impairment, while another prospective analysis found sleep disturbance was linked with both incident dementia as well as mortality. Furthermore, compared to cognitively normal individuals, those with either with self-reported obstructive sleep apnea (OSA) diagnosis or physician-diagnosed OSA, developed more Alzheimer’s disease biomarkers, such as amyloid-beta plaques or tau proteins, over time compared to those without OSA. In addition, previous research has found associations between both long (>9 hours) and short (9 hours) were associated with all-cause dementia and clinical Alzheimer disease, but not short sleep (<6 hours). However, according to meta-analysis of 27 studies, both short (< 7 hours) and long sleep duration (> 8 hours) were both associated with approximately 86% greater risk for Alzheimer’s disease and dementia. Prior research has also examined the association among sleep characteristics, sleep deficiency, alertness and all-cause mortality. In a prospective analysis, researchers found that older short (9 hours) was associated with greater risk of mortality. Therefore, research on sleep disturbance and deficiency and all-cause mortality has shown conflicting results. Further, few studies measure a comprehensive set of sleep characteristics in one study. We examine, using nationally representative longitudinal data collected among US adults, several sleep characteristics, dementia, and mortality across a 5-year follow-up duration.
10:00 – 11:30 AM ET
HMS DSM Annual Faculty Meeting
10:00 – 11:30 AM ET
Mary A. Carskadon, PhD Introductory Meeting with HMS DSM Trainees
12:00 – 1:15 PM ET
Division of Sleep Medicine Annual Prize Lecture by Mary A. Carskadon, PhD
1:15 – 1:30 PM ET
Awarding of 2020 Harvard Medical School Division of Sleep Medicine Prize to Mary A. Carskadon, PhD
3:00 – 4:30 PM ET
4:30 – 5:30 PM ET
6:00 – 7:00 PM ET
Evening Public Lecture by Mary A. Carskadon, PhD
“Changes in Sleep Biology Create a Perfect Storm Affecting Teen Health and Well-Being”