Menopause is a period unique to women during which there are major hormonal and physiological changes that affect women’s health and well-being. Sleep is often disturbed during the menopausal transition, which can further contribute to impaired daytime functioning. Understanding the impact of menopause-related changes in sleep is an important area of women’s health research. Here, we report the results of a study investigating the effects of a menopause model of sleep fragmentation and estradiol withdrawal on perceived sleep quality and daytime sleepiness.