Yan Tang, PhD

Pulmonary and Critical Care
Yan Tang*, David J. Kwiatkowski, Elizabeth P. Henske
Single cell analysis of Tuberous Sclerosis Complex (TSC) reveals a stem-like tumor state linked to immune suppression

mTORC1 is estimated to be hyperactive in at least half of all human malignancies. Here, we performed integrative analysis of single cell transcriptomic profiling, paired T cell receptor (TCR) sequencing, and spatial transcriptomic profiling on Tuberous Sclerosis Complex (TSC) associated tumors with mTORC1 hyperactivity, and identified a stem-like tumor cell state (SLS) linked to T cell dysfunction via tumor-modulated immunosuppressive macrophages. This study suggests a paracrine tumor survival mechanism via immune suppression adopted by the stem-like state tumor cells with mTORC1 hyperactivity. We also provide a comprehensive resource to advance the understanding of TSC and potentially other mTORC1-hyperactive tumors.