20th Annual Sleep and Health Benefit

Real-time breath metabolomics for circadian time determination

Marlen Menlyadiev, PhD

Brigham and Women's Hospital, Harvard Medical School

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Clinical Implications
Discovery of circadian biomarkers in the breath has the potential to enable simple, non-invasive, and fast approaches to determination of circadian time. This, in turn, would allow early interventions for maintaining long-term health and safety as well as enable accelerate advancements in related fields, such as chronopharmacology.
Research Narrative

Disrupted circadian timing has emerged as a serious health and safety issue, yet there are no objective means of easily assessing circadian timing or alignment without performing a highly controlled, multiple-day in-patient study. Altered circadian timing can cause both sleep loss and sleepiness, cause performance errors such as motor vehicle accidents, and impair memory/learning. We are, therefore, using real-time breath metabolomics technology called select ion flow tube mass spectrometry (SIFT-MS) to explore whether the molecular constituents of exhaled breath can be used to determine circadian time of the individual. The ultimate goal of this research to enable determination of the circadian status from a single breath at the point-of-care or point-of-need.

Research Category
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