20th Annual Sleep and Health Benefit

Coordination of Neural Oscillations in Patients with Hippocampal Intracranial Electrodes in Relation to Sleep-Dependent Memory Consolidation

Megan Thompson, PhD

Massachusetts General Hospital

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Clinical Implications
Our preliminary data shows increases in ripple density and amplitude in memory consolidation nights, implicating this oscillation’s role in sleep-dependent memory consolidation in humans and its potential as a clinical target for memory deficits. Future work will investigate ripples’ coordination with sleep spindles and slow oscillations during sleep.
Research Narrative

As a bioengineer with a specialization in neuroimaging, I have spent my career seeking to characterize the unique information visible through neural oscillations.

I investigated speech motor learning and associated neural oscillations during my PhD in the Biomagnetic Imaging Laboratory at the University of California, San Francisco under the mentorship of Professor Srikantan Nagarajan and Associate Professor John Houde. I continued in this research area during my postdoctoral research fellowship with Professor Frank Guenther’s lab at Boston University, where I studied cognitive predictions for speech motor control. Driven by the incomplete story of motor learning I observed from awake, same-day experiments, I joined Professor Dara Manoach’s lab to investigate the role of sleep in motor memory consolidation.

In Dr. Manoach’s lab at Massachusetts General Hospital, I have had the opportunity to investigate sleep and memory, in particular the coordination of sleep oscillations and their role in memory consolidation. This includes a rare chance to work with clinical patients who have had electrodes surgically implanted in their hippocampi, allowing us to observe specialized hippocampal oscillations that are not currently detectable via neuroimaging.

In my graduate and postgraduate career, I have showed a passion for neuroimaging and neurophysiology, in particular the role of neural oscillations in motor learning, production, and memory. By better characterizing these mechanisms, I hope to provide therapeutic targets to individuals with memory and learning deficits.

Research Category
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HMS DSM Annual Faculty Meeting

10:00 – 11:30 AM ET
Mary A. Carskadon, PhD Introductory Meeting with HMS DSM Trainees

12:00 – 1:15 PM ET
Division of Sleep Medicine Annual Prize Lecture by Mary A. Carskadon, PhD

1:15 – 1:30 PM ET
Awarding of 2020 Harvard Medical School Division of Sleep Medicine Prize to Mary A. Carskadon, PhD

3:00 – 4:30 PM ET
Poster Session

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Evening Public Lecture by Mary A. Carskadon, PhD

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