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Obstructive sleep apnea (OSA) is a common breathing disorder characterized by recurrent episodes of upper airway collapse with reduced airflow, oxygen desaturation and consequent intermittent hypoxia, as well as sleep disruption, which are implicated in increased risk of cardiovascular disease. Surprisingly, although there is a strong dose-response association between OSA and stroke, evidence of a link between OSA and coronary artery disease (CAD) is less certain. One possibility is that OSA is a “double-edged sword” with some positive as well as negative consequences for CAD event risk. At certain doses, intermittent hypoxia (IH) may reduce CAD event risk by ischemic preconditioning, with positive effects on angiogenesis, coronary collateralization and increased antioxidant production. By contrast, IH may increase CAD event risk via oxidative stress and inflammation. Simulataneously, sleep disruption can have effects on immune differentiation and signalling. We find evidence that pathway-specific genetic risk of CAD differs when comparing individuals with and without OSA. Elevated PS-PGRSs for the HIF-1 and Hematopoietic cell lineage pathways are nominally associated with excess risk of CAD in OSA, but elevated PS-PGRSs for the MAPK and VEGF pathways are associated with protection for CAD in OSA. The effect size of this pathway-dependent qualitative effect modification is large enough to multiply or cancel the estimated CAD effect due to OSA itself. This provides evidence that gene-by-environment interaction may play an appreciable role in understanding CAD risk in people with OSA.
10:00 – 11:30 AM ET
HMS DSM Annual Faculty Meeting
10:00 – 11:30 AM ET
Mary A. Carskadon, PhD Introductory Meeting with HMS DSM Trainees
12:00 – 1:15 PM ET
Division of Sleep Medicine Annual Prize Lecture by Mary A. Carskadon, PhD
1:15 – 1:30 PM ET
Awarding of 2020 Harvard Medical School Division of Sleep Medicine Prize to Mary A. Carskadon, PhD
3:00 – 4:30 PM ET
4:30 – 5:30 PM ET
6:00 – 7:00 PM ET
Evening Public Lecture by Mary A. Carskadon, PhD
“Changes in Sleep Biology Create a Perfect Storm Affecting Teen Health and Well-Being”