Tingting Zhao, PhD

Research Scientist in Bioinformatics
Neurology
Genomics and Bioinformatics Hub
Genomics and Bioinformatics Hub

Principal Investigator: Xianjun Dong

Authors: Tingting Zhao, Xianjun Dong
Lay Abstract

Our Genomics and Bioinformatics Hub provides collaborations, technical supports and trainings to students and researchers at Brigham and Harvard community. We assist researchers with their genome data analysis, grant writing and data publication. Our clients hold a great variety of research interests, ranging from basic research to clinical studies. Most of the data we assist to analyze are DNA and RNA sequencing data, generated from research model organisms such as mouse and rat to patient samples.

Analysis of genomic data using computational tools helps to reveal biological mechanisms in a massive parallel way that could not be achieved using classical experimental methods. For example, DNA sequencing analysis is able to detect hundreds to thousands of genes in parallel for DNA variants or modifications that may linked to certain phenotypes, RNA sequencing analysis investigate genome-wide gene expression levels that are relevant to potential diseases.

Scientific Abstract

Our Genomics and Bioinformatics Hub provides bioinformatic services and trainings to students and researchers at Brigham and Harvard community. We have two next-generation sequencing (NGS) machines free for Brigham and Harvard community to use, they are Illumina NextSeq and 10X Genomics Next Gem. We also provide a broad variety of next-generation sequencing (NGS) data analysis services, including gene expression data analysis, single-cell RNA sequencing data analysis, single-cell ATAC sequencing data analysis, spatial transcriptomics data analysis, chromatin immunoprecipitation (ChIP) sequencing data analysis, small RNA sequencing data analysis, variant calling from genotyping/WGS/WES data et.al. We assist for grant writing, NGS experiment design and research publication. Our hub additionally provides hand-on bioinformatic trainings to students and researchers at Harvard community. Our training includes basic bioinformatics tools, bash, R and advanced data analysis, e.g. NGS data analysis and scRNA-seq data analysis.

Clinical Implications
Using computational and biological tools, our Genomics and Bioinformatics Hub assists researchers with their genomic data analysis to reveal genomic changes that may linked to potential disease.

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